Lacrimal gland progenitor cell function

One of our research focuses is on the potential of stem/progenitor cells for lacrimal gland regeneration and treating diseases.

Growing lacrimal gland progenitor cells in re-aggregated 3D cell culture. (A) Epithelial cell progenitors grown in 3D re-aggregated culture form buds in 24–48 hours; (B) Progenitor cell cultures differentiate into ductal and acinar components; (C) Transverse section of one of the acinar components of the 3D reaggregated culture showing normal acinar structure.

With expertise in the cellular mechanisms of morphogenesis and tissue-specific stem cell differentiation, our group is currently leading the way in isolating and characterizing lacrimal gland stem/progenitor cells.

We have been at the forefront of advancing studies concerning lacrimal gland development and regeneration, pioneering a novel methodology and strategy for the successful transplantation of stem cells into compromised lacrimal glands. Notably, our recent investigation involved the transplantation of stem/progenitor cells into chronically inflamed lacrimal glands, yielding remarkable results in terms of the restoration of both gland structure and function.

Furthermore, we employ innovative cultivation system (reaggregation of lacrimal gland progenitor cells) has been instrumental in maintaining the inherent properties of progenitor cells. This system has found applications across multiple research projects, enhancing their effectiveness and insights.

Through our research, we have illuminated the potential of therapeutic intervention to modulate inflammation, representing a novel avenue for mitigating inflammation and promoting regenerative processes. Overall, our research holds great potential for the development of innovative therapies aimed at restoring lacrimal gland function in the context of both disease and injury.